Statistical Geneticist or Computational Postdoc - Complex Disease Genomics at Harvard Medical School
Location: Boston, Massachusetts
Type: Full Time
Preferred Education: Doctorate
Years of Experience:
2 - 4
A competitive salary will be provided commensurate with experience level.
We are seeking a highly qualified and motivated Statistical Geneticist, Biostatistician or a Postdoctoral Fellow with a strong background in statistics and computational biology interested in integrating human genetics and functional genomics to study the biological causes of complex eye diseases. The candidate will work under the supervision of Dr. Ayellet Segrè in the Ocular Genomic Institute and Department of Ophthalmology at Massachusetts Eye and Ear (MEE) that is a vibrant, multidisciplinary research community of geneticists, clinician scientists, experimental biologists, and computational biologists. MEE is a teaching hospital of Harvard Medical School and is an international leader for treatment and research in both Ophthalmology and Otolaryngology. The Segrè lab develops and applies statistical and computational methods that integrate large-scale human genetic association and sequencing studies with functional genomic data (e.g., eQTLs, single cell RNA-seq data) to identify causal regulatory mechanisms, genes, pathways and pathogenic cell types that lead to common eye diseases, with the ultimate goal of proposing new preventative and therapeutic targets for eye disease. The Segrè lab is also affiliated with the Broad Institute of Harvard and MIT and its Medical and Population Genetics community. To learn more about the lab and department please visit:https://www.asegrelab.org/ and https://oculargenomics.meei.harvard.edu/labs/
The successful candidate will have a strong background in biostatistics, statistical genetics, computational genomics, bioinformatics, or a related quantitative field, and strong programming skills, and should be excited to contribute to advancing the science and medicine of eye disease. Research experience with large-scale genomic data desired. Research projects may involve genetic analyses of whole genome and whole exome sequencing data of glaucoma and other eye diseases using, a pharmacogenetic study of diabetic retinopathy treatment,as part of a Diabetic Retinopathy Clinical Research Network genetics study, polygenic risk score analyses of large-scale genotype-phenotype Biobank studies, and integration of GWAS with single cell RNA-seq and other functional genomics data to identify novel genetic risk factors and biological processes associated with complex eye diseases.Being a member of our group will provide an opportunity to contribute to large research efforts in the rapidly evolving field of genomics and human disease.
If interested, please send your CV, a cover letter describing your previous research experience and future research interests, and contact information for 3 references to Dr. Ayellet Segrè: ayellet_segre [at] meei.harvard.edu.
REQUIRED EDUCATION AND EXPERIENCE:
Ph.D. in statistical genetics, (bio)statistics, computational genomics, bioinformatics, mathematics, computer science, or a related quantitative discipline required. If MSc level, several years of experience preferred
Strong programming skills and in-depth experience with several programming languages required, e.g., Python, R, Matlab, C++.
Experience with Unix/Linux environments required, including shell scripting.
Research experience with statistical analyses of large-scale data required; experience in the field of genomics and bioinformatics desired.
Demonstrate critical thinking, rigorous work, and ability to meet deadlines.
Strong personal skills, and excellent organization and verbal and written communication skills.
Ability to work effectively both independently and collaboratively in a fast-paced, academic environment and evolving field.
DESIRED EXPERIENCE AND SKILLS:
Research experience in statistical genetics, genomics, or next-generation sequencing desired.
Background in regression models, machine learning, statistical genetics, or computational genomics a plus.
A strong motivation to contribute to the development of statistical methods for genomic research of complex diseases.
Massachusetts Eye and Ear is an affirmative action/equal opportunity employer. MEE is a teaching hospital of Harvard Medical School and is an international leader for treatment and research in both Ophthalmology and Otolaryngology. The Segrè lab is part of the Ocular Genomic Institute and the Department of Ophthalmology at Massachusetts Eye and Ear (MEE) and works on integrative computational and statistical analyses of human genetics and functional genomics to uncover causal mechanisms of common eye diseases.
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