Doris Wagner Laboratory, University of Pennsylvania, Philadelphia
Two postdoctoral positions are available in my lab to investigate developmental and environmental reprogramming of cell fate and function in Arabidopsis in the context of chromatin. We study reprogramming in a variety of biological contexts using a combination of approaches.
Current Research focuses on
Epigenome reprogramming via selective tethering/removal, activation/inactivaton, or repurposing of chromatin regulators to modulate organism form and function or response to stress.
Regulatory principles that control initiation, growth and fate of axillary meristems to shape inflorescence architecture and enhance reproductive success in response to environmental and endogenous cues.
Some recent publications are appended below, more details about our work can be found at http://web.sas.upenn.edu/wagner-lab/ or https://hosting.med.upenn.edu/epigenetics/faculty/doris-wagner/.
The University of Pennsylvania Biology Department studies diverse topics in Biology at multiple scales and has an excellent core of Plant Biology research groups. The Wagner lab is also a member of the superb Penn Epigenetics Institute. Philadelphia is a vibrant and livable city, bike friendly and walkable, with great restaurants and other activities.
Those interested should submit a cover letter (1-2 pages) outlining their research interest and career goals, a current curriculum vitae, and names and contact information of three referees to firstname.lastname@example.org
Chung, Y., Zhu, Y., Wu,M.-F., Simonini, S., Armenta-Medina, A., Jin, R., østergaard, L., Gillmor, C.S., and Wagner, D. (2019) Auxin Response factors promote organogenesis by chromatin-mediated repression of the pluripotency gene SHOOTMERISTEMLESS. Nature Communications 10, 886.
Xiao, J., Jin, R., Yu, X., Shen, M., Wagner, J.D., Pai, A., Song, C., Zhuang, M., Klasfeld, S., He, C., Santos, A. M., Helliwell, C., Pruneda-Paz, J. L., Kay, S. A., Lin, X., Cui, S., Garcia, M. F., Clarenz, O., Goodrich, J., Zhang, X., Austin, R. S., Bonasio, R., Wagner, D. (2017). Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 in Arabidopsis. Nat Genet. 49 (10) 1546-1552
Wu MF*, Yamaguchi N*, Xiao J*, Bargmann B, Estelle M, Sang Y, and Wagner D (2015) Auxin-regulated chromatin switch directs acquisition of flower primordium founder fate. eLife 4:e09269. * equal contribution.
Yamaguchi, N., Winter, C., Wu, M-F., Kanno, Y., Yamaguchi, A., Seo, M., and Wagner, D. (2014) Gibberellin acts positively then negatively to control onset of flower formation in Arabidopsis. Science 344, 638-41.
The successful candidate should be about to complete or have recently completed their PhD and should have a strong publication record.
We look for an applicant that is able to work both independently and in a team, and is highly productive.
Proficiency in confocal imaging, protein purification/mass spec, genomic approaches or computational biology/modeling is desirable.
Internal Number: 09162019
About Doris Wagner, Universiy of Pennsylvania, Dept of Biology and Epigenetics Initsitute
Doris Wagner is a Professor in the Biology Department and in the Epigenetics Institute at the University of Pennsylvania. She did her PhD work on phytochrome B structure /function with Peter Quail in Berkeley and a Helen Hey Whitney foundation funded postdoc with Elliot Meyerowitz on activity of the LEAFY transcription factor.
Her lab at the University of Pennsylvania focuses on the reprogramming of cell identity and function during developmental transitions and in response to environmental inputs in plants. Plants as sessile organisms are an excellent experimental system to address this question as they tailor their final form and cell function to a changing environment to optimize growth and survival. We have shown that master transcriptional regulators, hormone response and chromatin state together orchestrate cell fate reprogramming in plants.